Anabolic steroids have their effective uses but abusing them can lead to a variety of health problems, one of them become popular in causing liver toxicity or damage. Although, documented reports proved that many types of dangerous side-effects from the abuse of anabolic steroids are becoming known and frequent. Most of the drugs that are being used as anabolic steroids are referred to as performance-enhancing drugs, also referred to as “doping”. These are used by athletes and bodybuilders and can cause a serious injurious problem to health. Anabolic steroids are synthetic derivatives of testosterone shown to increase muscle size and strength. In the U.S., it is illegal to use anabolic steroids without a prescription. They are used in certain conditions when prescribed by a doctor. It imparts in increasing bone strength and muscle mass that is beneficial for health. This might be indicated in delayed puberty, testosterone deficiency, and disorder like AIDS.
With long-term use of high dose of anabolic steroids leads to an increased risk of liver damage or might develop liver cancer. Frequent use makes them addictive and craving that has also been affected by the liver damage. Life-threatening complications are also seen in a body by the use of anabolic steroids and the most affected risk is associated with liver damage. Damage to the liver is evident when enzymes called aminotransferases to leak out of damaged liver cells into your bloodstream. Liver damage from anabolic steroids can also cause a condition called cholestasis. With this condition, bile, a digestive fluid made in liver and leaks out into the blood. Symptoms like itching, nausea, loss of appetite, dark urine and jaundice etc.
Don’t use alkylated steroids:
Only specific steroids can damage the liver i.e. alkylated steroids can give bad impact on liver function. Alkylated steroids are oral steroids that are:
- not able to eliminate toxins present in liver without letting them get in the blood
- avoid breakdown of toxins into the liver
- inhibits the excretory function of liver.
Oral steroids are C17-Alpha Alkylated (C17-aa), which refers to a structural change in the hormone at the 17th carbon position. The reason for this modification is to help the drugs survive the first pass through the liver, where they can enter your system and provide benefits. But the downside is that the C17-aa modification also makes oral steroids toxic to the liver and is not able to eliminate toxins. Due to the liver toxicity, oral steroid usage should be limited to a maximum of 8 weeks. But the liver is a recover organ that’s able to heal and rejuvenate itself. It does not mean that you should over-excited and do not take responsibility to protect your organs.
The severity of side-effects of oral steroids and other drugs simultaneously increased the risk of liver and makes them more hepatotoxic. This might be associated with fatty liver disease, hepatic tumours, chronic vascular injury, and acute cholestatic syndrome. These changes occur in the liver might be life-threatening or recoverable.
The chemical substitution occurring in testosterone occurring in the body in two forms are the 17-beta-esterification and the 17-alpha-alkylation. Testosterone is metabolized rapidly in the body; the esterification of the 17-beta-hydroxyl group makes the molecule more hydrophobic. The 17-alpha- alkylation induces the inhibition of metabolic deactivation by oxidation of the 17-beta hydroxy group in the liver, thus 17alpha-alkylated androgens can be effectively administered orally. Often the alkylation of the C-17 position of testosterone alters the relative anabolic potency about the masculinizing effects (androgenic steroids). The most used oral anabolic steroids are mesterolone, methandienone, methenolone, methandrostenolone, methyl testosterone, oxandrolone, stanozolol. The oral forms are resistant to immediate degradation and hepatotoxic.
The 17alpha-alkylated steroids can be medically used for increasing weight and muscle growth in catabolic states, for the treatment of aplastic anaemia and bone marrow failure, as well as off-label for doping purposes. All these types of steroids have been associated with cases of liver damage such as cholestatic jaundice, peliosis hepatis, nodular regeneration, hepatic adenoma and hepatocellular carcinoma. Oxymetholone and methyltestosterone, instead, have frequently been linked to hepatocellular carcinoma. Stanozolol, either following intramuscular or oral administration, causes liver damage.
Use non-alkylated steroids:
Use non-alkylated injectable steroid as a base if you want free from liver susceptible effects. The injectable agents have undergone esterification of the 17-beta-hydroxy group to make them more soluble in lipids, leading to a slower release of the steroid into circulation. When these esters of testosterone i.e. testosterone enanthate, cypionate, and deaconate are administered in an oily suspension, they are released very slowly into the aqueous plasma because of their hydrophobicity. This extends their duration of action. Indeed, an important metabolic pathway of testosterone and its synthetic derivative is oxidation of the 17-beta-hydroxy group with the formation of the 17-keto metabolites. These polar metabolites are biologically inactive in the body. The injectable steroids are boldenone undecylenate, nandrolone decanoate, nandrolone phenpropionate, nandrolone undecanoate, testosterone cypionate, testosterone enanthate, testosterone propionate, trenbolone, trenbolone acetate, stanozolol.
The use of oral steroids alone is contraindicated. It puts a high pressure in the liver. If you want to keep your liver healthy, take a stack of an injectable with an oral. This would be beneficial for bulking as well as cutting. The dosage will not be higher than 350-750mg per week of stack and cycle duration would not be exceeded beyond six weeks.
Take supplements to protect liver:
In order to be a responsible steroid user, you should supplement with a liver aid that provides all the building blocks needed to restore and repair your liver during and after oral steroid usage. N2Guard is the most-popular liver support product in the steroid world. In fact, no serious bodybuilder does an oral cycle without it. If you use oral steroids in a responsible fashion, your liver enzyme levels will only slightly increase on cycle, and return to normal levels shortly after use is discontinued. Beyond supplementing with a liver aid like N2Guard during and after your cycle, you should also avoid any other activities that may be stressful to your liver, including some medications and excessive alcohol consumption.
Benefits that N2Guard that occurs during and after the steroid cycle:
1. Protects liver from damage due to use of oral steroids.
2. Keeps water retention to a minimum.
3. Regulates blood pressure.
4. Balances cholesterol levels.
5. Cleanses the kidneys of steroid metabolites and excessive protein consumption.
6. Clears out androgen receptors, making your next cycle more effective.
7. Cleanses the blood from toxins and harmful metabolites.
8. Maintains healthy reproductive, skeletal and digestive systems.
Taking N2Guard with every cycle your body needs to make you stay healthy and can continue cycling of steroids. N2Guard also provides a therapeutic treatment to reverse some of the side effects from previous steroid abuse, without using a liver aid on cycle.
Of course, being a responsible steroid user and being pro-active is always the best way to minimize side effects. But it’s still in your best interest to take N2Guard with every cycle to prevent liver toxicity and other side effects.
N2Guard is being used by enhanced athletes across the world, and its popularity is growing exponentially due to product’s incredible effects. Use N2Guard with every single steroid cycle and give yourself the assurance that you will stay healthy during your cycle and beyond. It is essential that you use a proper liver aid during and after taking oral steroids. N2Guard is the motherload of all support supplements since it not only protects your health, but also the muscle gains you make on cycle potent ingredients.
Pros of using short cycles:
Choose short steroid cycle over long cycles. Short duration cycle keeps the liver activity is still in normal condition and steroid influence is not devastating. High steroid dosage for a long time is too dangerous for your health risk. If you want to make your steroid cycle longer then replacing orals with the injectables is necessary. Use injectable steroid which carries the same effects as oral did and start your cycle with the 7th week.
Take breaks during cycling:
Using more steroids continuously is not a productive method and leads to liver damage. The more steroids you take the higher resistance your body builds to it so that they become inefficient after a period of time. That’s why to take breaks and let the body detach from toxins that entered it during the time. Allow body time to get back in normal functioning. The liver has the property to regenerate itself if proper time is allowed. This property also works with other vital organs. After a while, you can get back in cycling.
Role of Liver and keeps it healthy:
The liver is your body’s primary fat-burning organ, and it regulates important sex hormones such as testosterone. A healthy and well-functioning liver will make fat-loss and muscle-building goals much easier to achieve. The simplest things you can do to keep your liver healthy include: avoiding excessive alcohol consumption; following a healthy diet; getting regular exercise; and avoiding certain medications if possible. Before getting involved in any steroid cycle, make sure your liver function is normal. Avoid use of oral steroid cycle if you already have liver issues. The above-mentioned points will not be entertained if your liver activity might be suffered from severity and danger.
1. Cleanses blood.
2. Regulates the supply of glucose.
3. Oxidizes stored adipose tissue (fat) into energy through transport to the mitochondria.
4. Manufactures essential body proteins involved in transporting substances in the blood, clotting the blood, and providing resistance to infection.
5. Regulation of sex hormones, thyroid hormones, cortisone, and adrenal hormones.
6. Regulation of the body’s cholesterol.
7. Production of bile salt, which immobilizes fatty acids and eliminates toxic substances from the body.
8. Regulation of essential vitamins and minerals, such as iron and copper.