PT-141 - Bremelanotide 1.5 mg

Category:- Hormones | Type:- Injection

Each vial contains: PT-141 (Bremelanotide)    1.5 mg

Pharmacological properties

Bremelanotide is 21% protein bound in serum. Bremelanotide is a 7 amino acid and so its metabolism consists of multiple hydrolysis reactions. 64.8% of a radio labelled dose is excreted in the urine and 22.8% of the dose is recovered in the feces. The half life of Bremelanotide is 2.7 hours (1.9-4.0 hours).

INDICATIONS  

Bremelanotide injection is used to treat women with hypoactive sexual desire disorder (HSDD; a low sexual desire that causes distress or interpersonal difficulty) who have not experienced menopause (change of life; the end of monthly menstrual periods); who have not had problems with low sexual desire in the past; and whose low sexual desire is not due to a medical or mental health problem, a relationship problem, or medication or other drug use.

PREGNANCY AND LACTATION

Pregnancy:

Few pregnancies in women exposed to bremelanotide in clinical trials are insufficient for determining whether there is a drug-associated risk  for major congenital disabilities, miscarriage, or adverse maternal or fetal outcomes.

 Lactation:

• There is no information on the presence of bremelanotide or its metabolites in human milk, the effects on the breastfed infant, or the effects on milk production
• Consider developmental and health benefits of breastfeeding along with the mother’s clinical need for the drug and any potential adverse effects on the breastfed infant from the drug or the underlying maternal condition.

WARNINGS AND PRECAUTIONS

Bremelanotide injection may cause darkening of the skin on certain parts of the body including the face, gums, and breasts. The chance of darkening skin is higher in people with darker skin color and in people who used Bremelanotide injection for eight days in a row.

DOSAGE AND DIRECTIONS FOR USE

It is usually injected as needed, at least 45 minutes before sexual activity.

Contraindications:

• Uncontrolled hypertension
• Known cardiovascular disease

SIDE EFFECTS

• nausea (most common after the first dose and usually lasts for about 2 hours)
• vomiting
• headache
• flushing
• nasal stuffiness
• cough
• tiredness
• dizziness
• pain, redness, bruising, itching, numbness, or tingling in the area where the medication was injected

DRUG INTERACTIONS

Bremelanotide has severe interactions with no other drugs. If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

OVERDOSAGE

NA

STORAGE INSTRUCTIONS:

Store in a cool dark, & dry place.