Rubic
Gel
For quick relief from Sprain & Strains.
Muscular Pain, Joint Pain, Low Back Pain.
Rubic Gel is a multi-action topical get for quick relief from Sprain & Strains,
Muscular Pain, Joint Pain, Low Back Pain.
Composition
|
Diclofenac Diethylammonium |
|
1.16%w/w |
|
(equivalent to Dic;pfenac Sodium) |
|
1% w/w |
|
Oleum Lini |
B.P.63 |
3%w/w |
|
Menthol |
I.P. |
8%w/w |
|
Methyl Salicylate |
I.P. |
10%w/w |
|
Mephenesin |
I.P.85 |
5%w/w |
|
Gel Base |
|
q.s. |
Pharmacology
Diclofenac Diethylammonium is systemically absorbed through
the skin, it inhibits the enzyme cyclo-oxygenase, thus reducing the formation of PGE2.
Moreover, it also increases the uptake of Arachidonic acid into the cellullar pool.
Oleum Lini contains predominantly Essential Fatty Acids i.e. µ Linolenic
acid. On percutaneous absorbtion, µ- Linolenic
acid gets converted to Elcosapentanoic acid(EPA). EPA is acted upon by cyclo-oxygahase
enzyme to produce prostaglandin E3 which is a weak inflammatory agent. Presence of EPA prevents the action of cyclo-oxygenase
on Archidonic acid which reduces its coversion to PGE2(a highly inflammatory agent). Presence of PGE3 itself modulates the
inflammatory response through a feedback machanism.
Menthol is a vasodiator. It dilates the
blood vessels, produces a feeling of coolness and produces anallgesia.
Methyl salicylate is a known anti-inflammatory agent
.
Mephenisn is a
internunical neurone blocking agent, its primary site of action is the spinal internunical
neurone which modulates reflexes maintaining muscle tone.
It is a centrally acting skeletal muscle relaxtant used for symtomatic
treatment of painful muscle spasm.
Indications:
Rublic Gel is indicated for the quick relief from pain,
swelling and inflalmmation due to musculo-skeletal disorders such as sprains, Strains,
tendinitis,bursitis, hands, neck & shoulder pain, sciatica, muscle stiffness, joint
pain, back ache and lumbago.
Dosage and application
Approximately one inch band of Rubic Gel should be applied
to the affected site three to four times daily with rubbing till the film disappears.
Presentation
Tube of 30 gm.
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